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In addition, AD has a complex pathogenesis due to the fact that mitochondrial dysfunction, inflammatory mechanisms and oxidative stress play a role in the production and development of the disease 25 clomid side effects for men A problem with the use of SERMs for this purpose however is that when they are used in people assigned male at birth in whom the gonads are intact and testosterone levels are not suppressed, they will induce substantial increases in gonadal testosterone production and circulating testosterone levels